Summary: Baker and colleagues developed a new algorithm called “Gain Route Identification and Timing In Cancer” (GRITIC) to uncover the path of chromosomal evolution in a tumor, particularly in the context of whole-genome duplication. Their approach found that tumors with genome doubling frequently take an indirect path from one copy number state to another. In addition, the timing of genome doubling within a tumor’s evolution impacts its consequences on downstream chromosomal instability. See related article by Baker et al., p. 1810

中文翻译：

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癌症基因组有时走的是最长的进化之路


摘要：Baker 及其同事开发了一种名为 “癌症中获得途径识别和计时”（GRITIC） 的新算法，以揭示肿瘤中染色体进化的路径，特别是在全基因组复制的情况下。他们的方法发现，基因组加倍的肿瘤经常采用从一种拷贝数状态到另一种拷贝数状态的间接路径。此外，肿瘤进化中基因组加倍的时间会影响其对下游染色体不稳定性的影响。参见 Baker 等人的相关文章，第 1810 页