We recently read an article by Struijk et al. [1] published in the Journal of Cachexia, Sarcopenia and Muscle entitled ‘Total Magnesium Intake and Risk of Frailty in Older Women’. This study provides valuable insight into the relationship between magnesium intake and risk of frailty in older women, with particular emphasis on the importance of dietary magnesium. I commend the authors for their thorough analysis and use of a large cohort study spanning several decades, which greatly strengthens the findings. However, there are a few points that I think deserve further discussion in order to round out this important study.

Firstly, in the article, the authors considered the effect of supplement use on the results of the study and adjusted for the use of magnesium supplements in the statistical analyses. However, there are several factors that need further consideration here that may affect the robustness of the study results. In the study, the data spanned a large period of time (1984 to 2010) and significant changes in healthcare and socio-economic conditions during this period may have introduced heterogeneity in the results. In addition, the formulations, brands and usage of supplements on the market may have changed over time and there may be instances where actual intake cannot be accurately captured. Future studies could therefore use mixed effects modelling or time series analysis to mitigate the impact of time variation on the results.

In addition, although the authors have adjusted for a variety of confounders, such as lifestyle, medication use and dietary factors, there are still a number of potential confounders that could have an impact on the robustness of the results. For example, previous studies have suggested that supplement users may already have certain health problems or concerns about future health [2], which may motivate them to use supplements more frequently. It is therefore difficult to determine whether the frailty outcomes are due to the effects of the supplements or to these underlying health problems. In addition, mental health status [3], social support [4] or environmental factors [5] may also influence the onset and progression of frailty. Future studies could consider using stratified analyses or taking these potential factors into account as covariates. Exploring these factors in depth would help to better understand the observed differences and provide stronger support for the reliability of the findings.

This also emphasizes the important role of social workers in the research and prevention of frailty syndromes, particularly in the older population. Through direct assistance, community involvement and support, and health promotion as well as lectures, social workers provide comprehensive support to older people to help them stay healthy and delay or prevent the onset of frailty. In addition, social workers work closely with professionals in the medical, nutritional and psychological fields to ensure that older persons receive comprehensive health management. This interdisciplinary collaboration allows for more effective prevention and management of frailty syndromes and improves the overall effectiveness of interventions.

In conclusion, the study by Struijk et al. provides an important foundation for a deeper understanding of the association between magnesium intake and frailty risk in older women [1]. However, to further enhance the accuracy and broad applicability of this study, we suggest that future research should place a greater emphasis on the temporal effects of supplement use and other potential confounders. At the same time, we also emphasize the key role of social workers in tackling frailty syndromes, who, through multilevel support and interdisciplinary collaboration, can significantly improve the health status and quality of life of older people. We believe that these recommendations will help future studies to achieve more comprehensive results in revealing the relationship between magnesium intake and frailty.

我们最近阅读了 Struijk 等人的一篇文章。 [ 1 ] 发表在《恶病质、肌肉减少症和肌肉杂志》上，题为“老年女性的总镁摄入量和虚弱风险”。这项研究为老年女性镁摄入量与虚弱风险之间的关系提供了宝贵的见解，特别强调了膳食镁的重要性。我赞扬作者对跨越数十年的大型队列研究进行了彻底的分析和使用，这极大地加强了研究结果。然而，我认为有几点值得进一步讨论，以完善这项重要的研究。

首先，在文章中，作者考虑了补充剂的使用对研究结果的影响，并在统计分析中根据镁补充剂的使用进行了调整。然而，有几个因素需要进一步考虑，这些因素可能会影响研究结果的稳健性。在这项研究中，数据跨越了很长一段时间（1984年至2010年），这段时期医疗保健和社会经济条件的重大变化可能导致结果存在异质性。此外，市场上补充剂的配方、品牌和用途可能会随着时间的推移而发生变化，并且可能存在无法准确获取实际摄入量的情况。因此，未来的研究可以使用混合效应模型或时间序列分析来减轻时间变化对结果的影响。

此外，尽管作者对生活方式、药物使用和饮食因素等各种混杂因素进行了调整，但仍然存在许多潜在的混杂因素可能会影响结果的稳健性。例如，之前的研究表明，补充剂使用者可能已经存在某些健康问题或对未来健康的担忧[ 2 ]，这可能会促使他们更频繁地使用补充剂。因此，很难确定虚弱的结果是由于补充剂的影响还是由于这些潜在的健康问题。此外，心理健康状况[ 3 ]、社会支持[ 4 ]或环境因素[ 5 ]也可能影响衰弱的发生和进展。未来的研究可以考虑使用分层分析或将这些潜在因素作为协变量考虑在内。深入探索这些因素将有助于更好地理解观察到的差异，并为研究结果的可靠性提供更有力的支持。

这也强调了社会工作者在衰弱综合症的研究和预防方面的重要作用，特别是在老年人群中。通过直接援助、社区参与和支持、健康促进和讲座，社会工作者为老年人提供全面的支持，帮助他们保持健康，延缓或预防衰弱的发生。此外，社会工作者与医疗、营养和心理领域的专业人士密切合作，确保老年人得到全面的健康管理。这种跨学科合作可以更有效地预防和管理衰弱综合症，并提高干预措施的整体有效性。

总之，Struijk 等人的研究。为更深入地了解老年女性镁摄入量与虚弱风险之间的关系提供了重要基础[ 1 ]。然而，为了进一步提高本研究的准确性和广泛适用性，我们建议未来的研究应更加重视补充剂使用的时间影响和其他潜在的混杂因素。同时，我们也强调社会工作者在应对衰弱综合症方面的关键作用，通过多层次的支持和跨学科的合作，可以显着改善老年人的健康状况和生活质量。我们相信，这些建议将有助于未来的研究在揭示镁摄入量与虚弱之间的关系方面取得更全面的结果。