CD8+ T cells are crucial in controlling infection with hepatitis B virus (HBV) but are functionally impaired during chronic HBV infection. Traditionally, these functional deficits have been associated with classical T cell exhaustion due to persistent antigenic stimulation. However, recent findings challenge this concept, emphasizing the multifactorial nature of T cell dysfunction in HBV infection. CD8+ T cells are functionally impaired during chronic HBV infection. Recent findings from preclinical models and studies of chronically infected humans have revealed surprising insights into the nature of the T cell dysfunction, which may open new avenues for therapeutic intervention.

中文翻译：

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超越耗竭：慢性 HBV 感染中 CD8+ T 细胞功能障碍的独特特征


CD8+ T 细胞在控制乙型肝炎病毒 （HBV） 感染方面至关重要，但在慢性 HBV 感染期间功能受损。传统上，这些功能缺陷与持续抗原刺激导致的经典 T 细胞耗竭有关。然而，最近的研究结果挑战了这一概念，强调了 HBV 感染中 T 细胞功能障碍的多因素性质。CD8+ T 细胞在慢性 HBV 感染期间功能受损。临床前模型和对慢性感染者的研究的最新发现揭示了对 T 细胞功能障碍性质的惊人见解，这可能为治疗干预开辟新的途径。