• Fe single-atom catalysts (h³-FNCs) with high loading, high catalytic activity and high stability were synthesized via a method capable of increasing both the metal loading and mass-specific activity by exchanging zinc with iron.

• The “density effect,” derived from the sufficiently high density of active sites, has been discovered for the first time, leading to a significant alteration in the intrinsic activity of single-atom metal sites.

• The superior oxidase-like catalytic performance of h³-FNCs ensures highly effective bacterial eradication.

中文翻译：

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高铁负载单原子催化剂通过密度效应促进 ROS 产生，实现高效抗菌治疗

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  通过锌与铁交换提高金属负载量和质量比活性的方法合成了具有高负载量、高催化活性和高稳定性的Fe单原子催化剂(h ³ -FNCs)。

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  首次发现了源自足够高密度的活性位点的“密度效应”，导致单原子金属位点的固有活性发生显着改变。

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  h ³ -FNC 卓越的类氧化酶催化性能确保高效消灭细菌。