Gastroparesis is a disorder of delayed gastric emptying with associated symptoms of postprandial fullness, early satiety, nausea, vomiting, bloating, and abdominal pain. Functional dyspepsia is an upper gastrointestinal disorder of gut–brain interaction that presents with similar symptoms but is defined according to symptom patterns rather than gastric motor dysfunction. Although delayed gastric emptying is a defining feature of gastroparesis, other aspects of gastric neuromuscular dysfunction, such as gastric accommodation and visceral hypersensitivity might contribute to symptoms. Similarly, although functional dyspepsia is not defined by impaired gastric emptying, disordered gastric motility might underlie pathogenesis in some patients with functional dyspepsia. In the last decade, it has been increasingly recognised that these two disorders might represent varying presentations along a common continuum of neuromuscular dysfunction, although with differentiating features with respect to outcomes, diagnosis, and treatments. In this Review, an overview of gastroparesis and functional dyspepsia from the perspective of gastric motility is provided, discussing what is distinct and what is shared between these disorders.

中文翻译：

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胃动力障碍


胃轻瘫是一种胃排空延迟性疾病，伴有餐后饱胀感、早饱、恶心、呕吐、腹胀和腹痛等相关症状。功能性消化不良是一种由肠-脑相互作用引起的上消化道疾病，表现为相似的症状，但根据症状模式而不是胃运动功能障碍来定义。虽然胃排空延迟是胃轻瘫的一个决定性特征，但胃神经肌肉功能障碍的其他方面，如胃调节和内脏超敏反应，也可能导致症状。同样，虽然功能性消化不良不是由胃排空受损定义的，但胃动力紊乱可能是一些功能性消化不良患者的发病机制的基础。在过去十年中，人们越来越认识到，这两种疾病可能代表神经肌肉功能障碍的常见连续体的不同表现，尽管在结果、诊断和治疗方面具有不同的特征。在本综述中，从胃动力的角度概述了胃轻瘫和功能性消化不良，讨论了这些疾病之间的区别和共同点。