Despite aging being one of the strongest risk factors for cancer, little is known about the biological mechanisms that promote tumor initiation. In this issue of Cancer Cell, Yan et al. address this fundamental question in the context of breast cancer and report that midkine is upregulated during the aging process and can promote tumorigenesis.

中文翻译：

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Midkine 将衰老与乳腺癌联系起来——癌症风险的新预测指标


尽管衰老是癌症最强的危险因素之一，但人们对促进肿瘤发生的生物学机制知之甚少。在本期 Cancer Cell 中，Yan 等人在乳腺癌的背景下解决了这个基本问题，并报告了 midkine 在衰老过程中上调，可以促进肿瘤发生。