Recent clinical success with metal-based radiopharmaceuticals has sparked an interest in the potential of these drugs for personalized medicine. Although often overlooked, the success and global impact of nuclear medicine is contingent upon the purity and availability of medical isotopes, commonly referred to as radiometals. For nuclear medicine to reach its true potential and change patient lives, novel production and purification techniques that increase inventory of radiometals are desperately needed. This tutorial review serves as a resource for those both new and experienced in nuclear medicine by providing a detailed explanation of the foundations for the production and purification of radiometals, stemming from nuclear physics, analytical chemistry, and so many other fields, all in one document. The fundamental science behind targetry, particle accelerators, nuclear reactors, nuclear reactions, and radiochemical separation are presented in the context of the field. Finally, a summary of the latest breakthroughs and a critical discussion of the threats and future potential of the most utilized radiometals is also included. With greater understanding of the fundamentals, fellow scientists will be able to better interpret the literature, identify knowledge gaps or problems and ultimately invent new production and purification pathways to increase the global availability of medical isotopes.

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从回旋加速器到色谱及其他：治疗诊断放射性金属的生产和纯化指南


最近金属基放射性药物的临床成功引发了人们对这些药物在个性化医疗中的潜力的兴趣。尽管核医学的成功和全球影响经常被忽视，但其有效性和全球影响取决于医用同位素（通常称为放射性金属）的纯度和可用性。为了使核医学发挥其真正的潜力并改变患者的生活，迫切需要增加放射性金属库存的新型生产和纯化技术。本教程回顾通过在一个文档中详细解释放射性金属的生产和纯化的基础，这些基础源于核物理学、分析化学和许多其他领域，为那些在核医学领域的新手和有经验的人提供了资源。该领域介绍了目标、粒子加速器、核反应堆、核反应和放射化学分离背后的基础科学。最后，还包括对最新突破的总结和对最常用放射性金属的威胁和未来潜力的批判性讨论。随着对基本原理的深入理解，科学家同行将能够更好地解释文献，识别知识差距或问题，并最终发明新的生产和纯化途径，以增加医用同位素的全球供应。