Background The purpose of this study was to report the incidence, time after inciting event, aetiology and risk after specific intraocular procedures and the visual outcomes associated with sympathetic ophthalmia (SO) occurrence. Methods This study reports data from multiple retrospective cohorts: retrospective population-based data were extracted from the TRICARE service network (between 2017 and 2021) and retrospective case-based data from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database (cohorts from the UK, South India and North India). Results There were 159 patients with SO identified. The length of time from sensitising event to SO occurrence was a median of 151 days (range: 6–9100 days). In the TRICARE database, 2 patients developed SO after open globe trauma and primary repair (of 615 eyes, rate 0.33%; 95% CI 1.26% to 1.30%). None developed SO after vitrectomy (total of 23 903 events; 95% CI 0% to 0.012%). The combined North Indian and UK cohorts reported 78.6% (81 patients) after trauma, 18.45% (19 patients) after elective surgery. Visual outcomes were reported in the OASIS database for 98.01% of patients (155 of 157 patients). The median presenting and final best corrected visual acuity (BCVA) for the inciting eye were no perception of light, the median presenting and final BCVA for the sympathising eye were 0.65 and 0.3 logMAR, respectively. Conclusion This study identified 159 cases of SO. With poor visual outcomes in the inciting eye, early diagnosis and management are crucial for optimising visual outcomes in the sympathising eye. Data may be obtained from a third party and are not publicly available.

中文翻译：

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交感性眼炎：流行病学和基于队列的临床结局评估


背景 本研究的目的是报告发病率、激发事件后的时间、特定眼内手术后的病因和风险以及与交感性眼炎 （SO） 发生相关的视觉结果。方法 本研究报告了来自多个回顾性队列的数据：回顾性基于人群的数据来自 TRICARE 服务网络（2017 年至 2021 年）和基于病例的回顾性数据来自眼自身免疫性全身炎症感染研究 （OASIS） 数据库（来自英国、南印度和北印度的队列）。结果 共确定 159 例 SO 患者。从致敏事件到 SO 发生的时间长度中位数为 151 天 （范围：6-9100 天）。在 TRICARE 数据库中，2 例患者在开放性眼球外伤和初次修复后发生 SO （615 只眼，率 0.33%;95% CI 1.26% 至 1.30%）。玻璃体切除术后无 SO 发生 （共 23 903 例事件;95% CI 0% 至 0.012%）。北印度和英国联合队列报告了 78.6% （81 名患者） 在创伤后，18.45% （19 名患者） 在择期手术后。OASIS 数据库中报告了 98.01% 的患者 （157 例患者中的 155 例） 的视觉结果。刺激眼的中位表现和最终最佳矫正视力 （BCVA） 是对光的无感知，交感眼的中位表现和最终 BCVA 分别为 0.65 和 0.3 logMAR。结论 本研究共纳入 159 例 SO。由于刺激眼的视力结果不佳，早期诊断和管理对于优化交感眼的视力结果至关重要。数据可能从第三方获得，并且不会公开。