The most common form of heart failure is heart failure with preserved ejection fraction (HFpEF). While heterogeneous in origin, the most common form of HFpEF is the cardiometabolic manifestation. Obesity and aging promote systemic inflammation that appears integral to cardiometabolic HFpEF pathophysiology. Accumulation of immune cells within the heart, fueled by an altered metabolome, contribute to cardiac inflammation and fibrosis. In spite of this, broad anti-inflammatory therapy has not shown significant benefit in patient outcomes. Thus, understanding of the nuances to metabolic and age-related inflammation during HFpEF is paramount for more targeted interventions. Here, we review clinical evidence of inflammation in the context of HFpEF and summarize our mechanistic understanding of immunometabolic inflammation, highlighting pathways of therapeutic potential along the way.

中文翻译：

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炎症对射血分数保留的心脏代谢心力衰竭的影响


最常见的心力衰竭形式是射血分数保留的心力衰竭 （HFpEF）。虽然起源异质性，但 HFpEF 最常见的形式是心脏代谢表现。肥胖和衰老会促进全身炎症，这似乎是心脏代谢 HFpEF 病理生理学不可或缺的一部分。免疫细胞在代谢组改变的推动下，在心脏内的积累导致心脏炎症和纤维化。尽管如此，广泛的抗炎疗法并未显示出对患者预后的显著益处。因此，了解 HFpEF 期间代谢和年龄相关炎症的细微差别对于更有针对性的干预措施至关重要。在这里，我们回顾了 HFpEF 背景下炎症的临床证据，并总结了我们对免疫代谢炎症的机制理解，强调了沿途的治疗潜力途径。