Background Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease which affects areas rich in apocrine glands. The main disease manifestations are inflammatory nodules (IN) and draining tunnels (dT). The course and progression of the disease are difficult to predict. There is currently lack of any broadly accepted biomarker which may inform on the activity of hidradenitis suppurativa (HS). Draining tunnel (dT) formation is the hallmark of HS in the affected skin. The existence of a biomarker which may predict dT formation before dTs appear in skin may become a tool for early biological treatment. Calprotectin, also known as S100 A8/A9 protein has been shown to be involved in various inflammatory conditions, including HS. Aim of this study was to evaluate circulating calprotectin as an index of dTs in the affected skin. Methods The study group consisted of 40 patients with confirmed HS and varying disease activity, assessed by number of dTs and International Hidradenitis Suppurativa Severity Score System (IHS 4 score) . Plasma samples were collected and stored at -80°C until analysis. Calprotectin was measured with GCAL® turbidimetric assay (Gentian AS, Norway). Results Fifteen patients had mild HS and 25 patients had moderate/severe HS. Positive association was found between circulating calprotectin and the absolute dT count (Pearson’s r2 = +0.750; p<0.0001) and the IHS4 (International HS 4 score) (Pearson’s r2 = +0.671; p<0.0001). Circulating calprotectin was significantly increased in patients with more than 2 dTs. Plasma calprotectin greater than 0.5 mg/L was associated with odds ratio 8.00 (1.87 to 34.22; p = 0.005) for 2 or more dTs. Conclusions Calprotectin is presented, for the first time, as a biomarker which indicates the formation of dTs in the skin. Its use as surrogate of early start of biologicals and response to treatment remains to be explored.

中文翻译：

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B-068 血浆钙卫蛋白作为化脓性汗腺炎引流通道形成的指标


背景 化脓性汗腺炎 (HS) 是一种慢性炎症性皮肤病，影响顶浆腺丰富的区域。主要疾病表现是炎性结节（IN）和引流管（dT）。该疾病的病程和进展很难预测。目前缺乏任何广泛接受的生物标志物可以告知化脓性汗腺炎（HS）的活动。引流通道 (dT) 的形成是受影响皮肤中 HS 的标志。在 dT 出现在皮肤之前预测 dT 形成的生物标志物的存在可能成为早期生物治疗的工具。钙卫蛋白，也称为 S100 A8/A9 蛋白，已被证明与多种炎症性疾病有关，包括 HS。本研究的目的是评估循环钙卫蛋白作为受影响皮肤 dT 的指标。方法 研究组由 40 名确诊 HS 且疾病活动度不同的患者组成，通过 dT 数量和国际化脓性汗腺炎严重程度评分系统（IHS 4 评分）进行评估。收集血浆样品并储存在-80°C直至分析。使用 GCAL® 比浊法（Gentian AS，挪威）测量钙卫蛋白。结果 15例患者为轻度HS，25例患者为中重度HS。循环钙卫蛋白与绝对 dT 计数（Pearson's r2 = +0.750；p<0.0001）和 IHS4（国际 HS 4 评分）（Pearson's r2 = +0.671；p<0.0001）之间存在正相关。 dT 超过 2 的患者中循环钙卫蛋白显着增加。对于 2 个或更多 dT，血浆钙卫蛋白大于 0.5 mg/L 与比值比 8.00（1.87 至 34.22；p = 0.005）相关。 结论 钙卫蛋白首次作为指示皮肤 dT 形成的生物标志物出现。其作为早期开始使用生物制剂和治疗反应的替代指标的用途仍有待探索。