Background An association between uric acid and kidney disease, glucose intolerance, high blood pressure, metabolic syndrome and cardiovascular disease has been recognized. It is the obligation of the Clinical Laboratory to have valid reference intervals (RI) for this marker. Each particular population has genetics and a diet that represents it, which cannot be extrapolated in many cases. The difficulty and high cost of using direct methods for its establishment drive us to use the existing data in our electronic archive retrospectively. Objective: to describe the range of uric acid values in adult outpatients treated at the Posadas Hospital during the year 2022. Evaluate the influence of gender and age range on the observed values. Methods A retrospective observational approach was carried out from the System database Laboratory Informatics (SIL), Roche Infinity, from the year 2022. The data corresponding to all adult outpatient patients treated in the service were processed. Analytical System: Roche Cobas 6000, Uricase-Oxidase method. Exclusion criteria: oncology patients, kidney patients, diabetics, hyperglycemic patients, obstetric patients, hormonal patients, treated in wards and referred patients. Outliers excluded by Tukey method. The statistical treatment was carried out with the SPSS 17.0 program. Results We worked with 91922 data groups. Hence 12331 of uric acid. After meeting the exclusion criteria: 3899, of which 2289 (3.96 ± 1.05 mg/dl) correspond to women < 50 years , 747 (4.36 ± 1.15 mg/dl at ≥ 50 years and 863 (5.59 ± 1.33 mg/dl) men, all with normal distributions. Applying ANOVA and Student's test it was possible to verify in addition to the described significant difference between sexes, a difference between the 2 age groups of women (p<0.01) which is not equal to that of men in women ≥ 50 years of age. Conclusions A more extensive study is necessary to define own reference ranges that enable the early alarm guidelines, especially in the group of women < 50 years of age. This will allow an adequate evaluation of risk and evolution of patients. The application of Indirect Methods will make it possible to exclude values corresponding to underlying pathologies not registered in the SIL.

中文翻译：

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B-133 尿酸：2022 年在高复杂性医院接受治疗的成年患者中发现的值的描述


背景 人们已经认识到尿酸与肾脏疾病、葡萄糖耐受不良、高血压、代谢综合征和心血管疾病之间存在关联。临床实验室有义务为此标记物制定有效的参考区间 (RI)。每个特定人群都有代表它的遗传学和饮食，但在许多情况下无法推断。采用直接方法建立的难度和成本较高，促使我们回顾性地使用电子档案中的现有数据。目的：描述 2022 年波萨达斯医院成人门诊患者的尿酸值范围。评估性别和年龄范围对观测值的影响。方法 从 2022 年开始，对 Roche Infinity 实验室信息学 (SIL) 系统数据库进行回顾性观察。处理了与该服务中所有成人门诊患者相对应的数据。分析系统：Roche Cobas 6000，尿酸酶-氧化酶法。排除标准：肿瘤患者、肾病患者、糖尿病患者、高血糖患者、产科患者、激素患者、病房治疗和转诊患者。通过 Tukey 方法排除异常值。采用SPSS 17.0程序进行统计处理。结果 我们处理了 91922 个数据组。因此尿酸为12331。满足排除标准后：3899 例，其中 2289 例（3.96 ± 1.05 mg/dl）对应女性 < 50 岁，747 例（4.36 ± 1.15 mg/dl ≥ 50 岁）和 863 例（5.59 ± 1.33 mg/dl）男性，均采用正态分布，应用方差分析和学生检验，除了所描述的性别之间的显着差异之外，还可以验证 2 个年龄组女性之间的差异 (p<0.01) 不等于≥ 50 岁女性中的男性。结论 需要进行更广泛的研究来定义自己的参考范围，以实现早期警报指南，特别是在 < 50 岁的女性群体中。这将有助于对患者的风险和演变进行充分的评估。间接方法的应用将可以排除与未在 SIL 中注册的潜在病理相对应的值。