The concept of frailty, now being adopted in most medical disciplines, is attracting growing interest in neurology. Every day, most neurologists care for patients with varying degrees of frailty, from very mild to very severe. Frailty exacerbates patients' health needs, complicates clinical decision making, and negatively affects their health outcomes. Increasing evidence suggests that frailty affects the risk, clinical presentation, and course of common age-related neurological disorders, including dementia, Parkinson's disease, stroke, and multiple sclerosis. Most neurologists should become familiar with assessing and measuring frailty. Doing so can provide information that is crucial for diagnosis, prognostication, and care planning. Consideration of frailty can help to elucidate the pathophysiological underpinnings of age-related neurological disorders, clarify the clinical validity and utility of candidate biomarkers, and identify novel therapeutic targets. Randomised controlled trials investigating late-life neurological diseases that address frailty have the potential to provide insight into these complex disorders.

中文翻译：

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神经科医生的虚弱：关于虚弱如何影响护理计划的观点


衰弱的概念现在被大多数医学学科采用，引起了人们对神经病学的日益增长的兴趣。每天，大多数神经科医生都会照顾不同程度虚弱（从非常轻微到非常严重）的患者。虚弱加剧了患者的健康需求，使临床决策复杂化，并对他们的健康结果产生负面影响。越来越多的证据表明，虚弱会影响常见年龄相关神经系统疾病的风险、临床表现和病程，包括痴呆、帕金森病、卒中和多发性硬化症。大多数神经科医生应该熟悉评估和测量虚弱。这样做可以提供对诊断、预后和护理计划至关重要的信息。考虑虚弱有助于阐明与年龄相关的神经系统疾病的病理生理学基础，阐明候选生物标志物的临床有效性和效用，并确定新的治疗靶点。调查解决虚弱的晚年神经系统疾病的随机对照试验有可能提供对这些复杂疾病的见解。