We read with interest the FluDReSS trial by Walsham et al., which investigated the dose–response relationship of enteric fludrocortisone in patients with septic shock [1]. Notably, while significant changes in plasma concentrations were observed, these changes were not correlated with dosage. Furthermore, no benefits in terms of sepsis resolution or mortality were reported. While we commend the authors for the completion of this important trial, we would like to address several concerns.

中文翻译：

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氟氢可的松是感染性休克中缺失的部分吗？仔细观察

我们饶有兴趣地阅读了 Walsham 等人的 FluDReSS 试验，该试验研究了脓毒性休克患者肠道氟氢可的松的剂量-反应关系 [1]。值得注意的是，虽然观察到血浆浓度的显着变化，但这些变化与剂量无关。此外，未报告脓毒症消退或死亡率方面的益处。虽然我们赞扬作者完成了这项重要的试验，但我们想解决几个问题。