ObjectiveAssess whether horizontal ridge augmentation with guided bone regeneration (GBR) using deproteinized bovine bone mineral (DBBM), autologous bone, and a resorbable collagen membrane supports successful implant placement.Materials and MethodsThis open, prospective, single‐cohort, multicenter clinical study included patients with ridge defects that required GBR prior to implant insertion. The primary endpoint was radiologically assessed bone gain after 8 months post‐GBR, measured at the center of planned implant sites. Secondary endpoints included implant survival and success, marginal bone levels (MBLs), MBL changes, and soft tissue health.ResultsOf 45 patients evaluated 8 months post‐GBR, nine experienced dehiscence in the first 3 weeks of the healing period. GBR led to radiologically determined mean bone width gain of 4.0 ± 1.5 mm and 4.8 ± 1.7 mm, measured 1 and 3 mm from the top of the crest, respectively, allowing successful implant placement in 44 patients (97.8%). The cumulative implant survival and success rates were 98.9% and 95.5%, respectively. MBLs were stable: −1.18 ± 0.64 mm at definitive prosthesis placement (DPP) and − 1.07 ± 0.74 mm at 1 year. Soft tissue health and esthetics (plaque and bleeding indices, papilla, keratinized mucosa, and pink esthetic score) improved from DPP to 1 year. Patients were highly satisfied with implant function and esthetics, and their oral health‐related quality of life improved.ConclusionsGBR using DBBM and a collagen membrane offered a safe and effective treatment option for horizontal ridge augmentation sufficient to support implant‐based tooth rehabilitation.Trial RegistrationRegistered at ClinicalTrials.gov NCT03028922 (registrations sites, as above listed affiliations, first posted January 23, 2017)

中文翻译：

---

下颌后部水平引导骨再生以允许种植体植入：一年前瞻性研究结果


目的评估使用脱蛋白牛骨矿物质 (DBBM)、自体骨和可吸收胶原膜的引导骨再生 (GBR) 水平牙槽嵴增强是否支持成功的种植体植入。材料和方法这项开放、前瞻性、单队列、多中心临床研究包括患者牙槽嵴缺损，需要在植入种植体之前进行 GBR。主要终点是 GBR 后 8 个月后的放射学评估骨增益，在计划植入部位的中心进行测量。次要终点包括种植体存活率和成功率、边缘骨水平 (MBL)、MBL 变化和软组织健康。结果 在 GBR 后 8 个月对 45 名患者进行评估，其中 9 名患者在愈合期的前 3 周内出现裂开。 GBR 导致放射学确定的平均骨宽度增加为 4.0 ± 1.5 毫米和 4.8 ± 1.7 毫米（分别从牙槽嵴顶部测量 1 毫米和 3 毫米），从而使 44 名患者 (97.8%) 成功植入种植体。累积种植体存活率和成功率分别为98.9%和95.5%。 MBL 稳定：最终假体植入 (DPP) 时为 -1.18 ± 0.64 毫米，1 年时为 - 1.07 ± 0.74 毫米。从 DPP 到 1 年，软组织健康和美观（斑块和出血指数、乳头、角化粘膜和粉红色美学评分）有所改善。患者对种植体功能和美观非常满意，与口腔健康相关的生活质量得到改善。结论使用 DBBM 和胶原膜的 GBR 为水平牙槽嵴增高提供了安全有效的治疗选择，足以支持基于种植体的牙齿康复。试验注册已注册位于 ClinicalTrials.gov NCT03028922（注册网站，如上面列出的隶属关系，首次发布于 2017 年 1 月 23 日）