The Hierarchical Taxonomy of Psychopathology (HiTOP) framework offers the potential to better understand how neurobiological mechanisms relate to psychopathology. The P300 is an event-related potential component that indexes attention, stimulus evaluation, and categorization. A blunted P300 has been associated with psychiatric disorders across externalizing, internalizing, and thought disorder domains. However, there has been little research investigating whether the P300 is related to higher-order dimensions of psychopathology. In a sample of 225 adults aged 18-35 years (Mage = 23.09, SD = 3.83, 82.2% female) who were oversampled for psychopathology, the present study examined the associations between the P300 and both psychopathology spectra and a general factor. Participants completed multiple experimental tasks, while electroencephalography was recorded to measure the P300 elicited by auditory, tactile, and visual stimuli. Participants also completed the self-report Comprehensive Assessment of Traits Relevant to Personality Disorder to assess pathological personality dimensions. We used structural equation modeling to examine the relationship between a latent P300 factor and both psychopathology spectra (negative emotionality, detachment, psychoticism, disinhibition, and antagonism) and a general factor. The results indicated that the P300 was inversely related to the general factor. Further analyses revealed no relationships between the P300 and any individual spectrum when accounting for the general factor. Overall, the present study indicates that the P300 is associated with the general factor of psychopathology, which might explain its association with multiple categorical disorders. The study also demonstrates the potential importance of neuroscience-informed dimensional systems to understand clinical phenomena. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译：

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精神病理学的 P300 和层次维度。


精神病理学层次分类法 (HiTOP) 框架提供了更好地理解神经生物学机制与精神病理学之间关系的潜力。 P300 是一个与事件相关的电位组件，用于索引注意力、刺激评估和分类。 P300 减弱与外化、内化和思维障碍领域的精神疾病有关。然而，很少有研究调查 P300 是否与精神病理学的高阶维度相关。在对 225 名 18-35 岁成年人（Mage = 23.09，SD = 3.83，82.2% 女性）进行精神病理学过采样的样本中，本研究检查了 P300 与精神病理学谱和一般因素之间的关联。参与者完成多项实验任务，同时记录脑电图以测量听觉、触觉和视觉刺激引起的 P300。参与者还完成了自我报告的人格障碍相关特征综合评估，以评估病态人格维度。我们使用结构方程模型来检查潜在 P300 因子与精神病理学谱（消极情绪、疏离、精神病、去抑制和对抗）和一般因子之间的关系。结果表明，P300与一般因子呈负相关。进一步的分析表明，在考虑一般因素时，P300 与任何单个频谱之间没有关系。总体而言，本研究表明 P300 与精神病理学的一般因素相关，这可能解释其与多种分类疾病的关联。 该研究还证明了基于神经科学的维度系统对于理解临床现象的潜在重要性。 （PsycInfo 数据库记录 (c) 2024 APA，保留所有权利）。