Among people infected with measles in England between 2010 and 2019, the proportion of cases who had previously received two doses of vaccine has increased, especially among young adults. Possible explanations include rare infections in vaccinated individuals who did not gain immunity upon vaccination, made more common because fewer individuals in the population were born in the endemic era, before vaccination was introduced, and exposed as part of endemic transmission, or the waning of vaccine-induced immunity, which would present new challenges for measles control in near-elimination settings. We aimed to evaluate whether measles dynamics observed in England between 2010 and 2019 were in line with a waning of vaccine-induced immunity.

中文翻译：

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英格兰疫苗诱导的麻疹免疫力长期减弱：一项数学建模研究


在 2010 年至 2019 年期间英格兰感染麻疹的人群中，以前接种过两剂疫苗的病例比例有所增加，尤其是在年轻人中。可能的解释包括接种疫苗的个体在接种疫苗后没有获得免疫力的罕见感染，由于在引入疫苗接种之前，人口中出生的个体较少，并作为地方性传播的一部分而暴露，或者疫苗诱导的免疫力减弱，这将为在接近消除的环境中控制麻疹带来新的挑战。我们旨在评估 2010 年至 2019 年间在英格兰观察到的麻疹动态是否与疫苗诱导免疫力的减弱一致。