Incorporating labile bonds in the chemical structure of polymers yields interesting materials that are responsive to changes in environmental stimuli, such as pH. Active agents can be conjugated to various polymers through acid-labile linkages, conferring upon them spatiotemporal control over the cleavage and subsequent release of drugs, antibacterial agents or corrosion inhibitors. One key factor influencing the release of active agents is the hydrolytic stability of the linkages. We compared the hydrolytic kinetics of acid-cleavable linkages and discuss the effect of structural fine tuning of molecules on the hydrolysis rate. Synthetic routes towards various acid-sensitive linkages are discussed in relation with the functional unit available on the active substances to be released.

中文翻译：

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制备具有可裂解键的聚合物的策略，在酸性介质中释放活性剂


在聚合物的化学结构中加入不稳定键可以产生对环境刺激（如 pH 值）变化做出反应的有趣材料。活性剂可以通过酸不稳定键与各种聚合物偶联，赋予它们对药物、抗菌剂或缓蚀剂的裂解和随后释放的时空控制。影响活性剂释放的一个关键因素是键的水解稳定性。我们比较了酸可裂解键的水解动力学，并讨论了分子结构微调对水解速率的影响。讨论了与待释放的活性物质上可用的功能单元相关的各种酸敏感键的合成途径。