Determining the ligandability of the human proteome can provide key insights to characterize biological processes and promote drug discovery. Now, multi-tiered activity-based protein profiling provides comprehensive proteomic maps of chiral small-molecule interactions. Over 300 distinctive proteins were identified to ligand tryptoline acrylamides, including stereoselective and site-specific events.

中文翻译：

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绘制立体选择性相互作用的配体蛋白质组图


确定人类蛋白质组的配体性可以为表征生物过程和促进药物发现提供重要见解。现在，基于活性的多层蛋白质分析提供了手性小分子相互作用的全面蛋白质组图谱。超过 300 种独特的蛋白质被鉴定为配体色氨酸丙烯酰胺，包括立体选择性和位点特异性事件。