The incidence of detrusor underactivity is projected to rise owing to an ageing population and the increasing prevalence of diabetes, but therapeutic options remain limited. Successful bladder contractions have been yielded in studies of bladder pacing in animals. However, anatomical incongruities highlight the need for human trials. Bladder pacing in humans through electrical stimulation has shown some potential, although sustainable protocols are lacking owing to detrusor–sphincter dyssynergia and patient discomfort during trials. Thus, manometric studies in brain-dead patients might serve as a model for developing an implantable bladder pacing device to restore contractility.

中文翻译：

---

电刺激膀胱收缩功能减退


由于人口老龄化和糖尿病患病率的增加，逼尿肌活动不足的发生率预计会上升，但治疗选择仍然有限。在动物膀胱起搏研究中已经实现了成功的膀胱收缩。然而，解剖学上的不协调凸显了人体试验的必要性。尽管由于逼尿肌-括约肌协同失调和试验期间患者不适，缺乏可持续的方案，但通过电刺激对人体进行膀胱起搏已显示出一定的潜力。因此，脑死亡患者的测压研究可以作为开发可植入膀胱起搏装置以恢复收缩力的模型。