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Impact of IgG Fc Glycosylation on Disease Dynamics in Patients With Primary Sjögren Disease
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2024-09-29 , DOI: 10.1002/art.43018
Helena Achten, Leander Meuris, Liselotte Deroo, Matthias Jarlborg, Tine Decruy, Joke Deprez, Emilie Dumas, Kristel De Boeck, Eva Genbrugge, Wouter Bauters, Frederick Dochy, David Creytens, Dimitri Roels, Nico Callewaert, Dirk Elewaut, Isabelle Peene

Glycans attached to the Fc region of IgG antibodies influence their pro- or anti-inflammatory effector function. We aimed to explore the interrelation of the Fc glycosylation profile and disease transition, disease activity, and outcome in patients with suspected and confirmed primary Sjögren disease (SjD).

中文翻译:


IgG Fc 糖基化对原发性干燥病患者疾病动态的影响



附着在 IgG 抗体 Fc 区的聚糖会影响其促炎或抗炎效应功能。我们旨在探讨疑似和确诊原发性干燥症 (SjD) 患者的 Fc 糖基化谱与疾病转化、疾病活动和结局的相互关系。
更新日期:2024-09-29
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