Photodynamic therapy (PDT) as a clinical method relies on appropriate light delivery to activate photosensitizers, usually necessitates the utilization of cumbersome surgical instruments and high irradiation intensity, along with the requirement for hospitalization. To extend the applicability of PDT beyond hospital for better patient mobility, we design a wearable and self-powered metronomic PDT (mPDT) system for chronic wound infection treatment. A flexible alternative current electroluminescent (ACEL) device is constructed through sandwiching an emissive layer between conductive hydrogel electrodes. This ACEL device works as a therapeutic patch by loading photosensitizer (PS) in its bottom hydrogel electrode, thus aviods the intravenous administration to patients. Under the triboelectric nanogenerator generated AC pulse, the electroluminescence produced from emissive layer can be absorbed by the PS-loaded electrode to generate reactive oxygen species for mPDT. Benefited from its arbitrary tailorability, this device can be customized into on-demand shapes and sizes. Using diabetic infected wound as a model condition, this ACEL mPDT device effectively eliminates drug-resistant bacteria and accelerates wound healing. Thus, the body-worn optoelectronic device successfully avoids the utilization of extracorporeal physical light and power sources, providing a promising strategy for convenient, user-friendly, and prolonged treatment of superficial diseases.

光动力疗法（PDT）作为一种临床方法，依靠适当的光传输来激活光敏剂，通常需要使用笨重的手术器械和高照射强度，并且需要住院治疗。为了将 PDT 的适用性扩展到医院之外，以改善患者的活动能力，我们设计了一种可穿戴式自供电节拍 PDT (mPDT) 系统，用于慢性伤口感染治疗。通过在导电水凝胶电极之间夹入发射层来构建柔性交流电致发光（ACEL）装置。该ACEL装置通过在其底部水凝胶电极中加载光敏剂（PS）来充当治疗贴片，从而避免对患者进行静脉注射。在摩擦纳米发电机产生的交流脉冲下，发射层产生的电致发光可以被负载PS的电极吸收，产生用于mPDT的活性氧。得益于其任意可定制性，该设备可以根据需要定制形状和尺寸。这款 ACEL mPDT 设备以糖尿病感染伤口为模型，可有效消除耐药细菌并加速伤口愈合。因此，体戴式光电设备成功地避免了体外物理光和电源的使用，为方便、用户友好和长期治疗浅表疾病提供了一种有前途的策略。