This review explores the fascinating world of molecules featuring multiple stereogenic elements, unraveling the different strategies designed over the years for their enantioselective synthesis. Specifically, (dynamic) kinetic resolutions, desymmetrisations and simultaneous installation of stereogenic elements exploiting either metal- or organo-catalysis are the principal approaches to efficiently create and control the three-dimensional shapes of these attractive molecules. Although most molecules presented in this review possess a stereogenic carbon atom in combination with a stereogenic axis, other combinations with helices or planes of chirality have started to emerge, as well as molecules displaying more than two different stereogenic elements.

中文翻译：

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具有多种立体元件的分子的对映选择性合成


这篇综述探讨了具有多种立体元素的分子的迷人世界，揭示了多年来为其对映选择性合成设计的不同策略。具体来说，（动态）动力学分辨率、去对称化和同时安装利用金属或有机催化的立体元件是有效创造和控制这些吸引分子的三维形状的主要方法。尽管本综述中介绍的大多数分子都具有立体碳原子和立体轴的组合，但其他具有螺旋或手性平面的组合已经开始出现，以及显示两种以上不同立体元素的分子。