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Primaquine for uncomplicated Plasmodium vivax malaria in children younger than 15 years: a systematic review and individual patient data meta-analysis
The Lancet Child & Adolescent Health ( IF 19.9 ) Pub Date : 2024-09-24 , DOI: 10.1016/s2352-4642(24)00210-4
Robert J Commons FRACP, Megha Rajasekhar PhD, Elizabeth N Allen PhD, Prof Daniel Yilma MD, Palang Chotsiri PhD, Tesfay Abreha MPH, Prof Ishag Adam PhD, Ghulam Rahim Awab PhD, Bridget E Barber PhD, Larissa W Brasil PhD, Cindy S Chu MD, Prof Liwang Cui PhD, Peta Edler MBiostat, Margarete do Socorro M Gomes PhD, Lilia Gonzalez‑Ceron PhD, Matthew J Grigg PhD, Muzamil Mahdi Abdel Hamid PhD, Jimee Hwang MD, Harin Karunajeewa PhD, Prof Marcus V G Lacerda PhD, Simone Ladeia-Andrade PhD, Toby Leslie PhD, Rhea J Longley PhD, Prof Wuelton Marcelo Monteiro PhD, Prof Ayodhia Pitaloka Pasaribu PhD, Jeanne Rini Poespoprodjo MD, Caitlin L Richmond MPH, Komal Raj Rijal PhD, Walter R J Taylor FRCP, Pham Vinh Thanh PhD, Kamala Thriemer PhD, José Luiz F Vieira PhD, Prof Nicholas J White FRS, Lina M Zuluaga-Idarraga PhD, Lesley J Workman MPH, Prof Joel Tarning PhD, Kasia Stepniewska PhD, Prof Philippe J Guerin MD, Prof Julie A Simpson PhD, Prof Karen I Barnes FCCP, Prof Ric N Price FRCP, WorldWide Antimalarial Resistance Network Paediatric Primaquine Vivax Study Group, Bipin Adhikari, Mohammad Shafiul Alam, Nicholas M Anstey, Ashenafi Assefa, J Kevin Baird, Sarah C Boyd, Nguyen H Chau, Nicholas PJ Day, Tamiru Shibiru Degaga, Arjen M Dondorp, Annette Erhart, Marcelo U Ferreira, Prakash Ghimire, Wasif A Khan, Benedikt Ley, Asrat H Mekuria, Ivo Mueller, Mohammad N Naadim, Francois Nosten, David J Price, Sasithon Pukrittayakamee, Mark Rowland, Jetsumon Sattabongkot, Guilherme SuarezKurtz, Inge Sutanto, Lorenz von Seidlein, Timothy William, Charles J Woodrow, Adugna Woyessa

Primaquine, the only widely available treatment to prevent relapsing Plasmodium vivax malaria, is produced as 15 mg tablets, and new paediatric formulations are being developed. To inform the optimal primaquine dosing regimen for children, we aimed to determine the efficacy and safety of different primaquine dose strategies in children younger than 15 years.

中文翻译:


伯氨喹治疗 15 岁以下儿童无并发症的间日疟原虫疟疾:系统评价和个体患者数据荟萃分析



伯氨喹是唯一一种广泛可用的预防间日疟原虫疟疾复发的治疗方法,生产为 15 毫克片剂,并且正在开发新的儿科制剂。为了告知儿童的最佳伯氨喹给药方案,我们旨在确定不同伯氨喹剂量策略对 15 岁以下儿童的有效性和安全性。
更新日期:2024-09-24
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