Podocytes possess immune system components allowing for a variety of innate responses to endogenous and exogenous stimuli. Recently, several groups have linked inappropriate innate immune signaling to podocyte injury, particularly chronic, sustained injury; however, the immune capabilities of podocytes have not been fully elucidated. Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from damaged cells, including podocytes, and can elicit an inflammatory response and recruit immune cells to areas of injury. This is performed through binding to pattern recognition receptors. Believed largely to be protective and responsive to injury or infection, recent evidence suggests signaling through DAMP pathways can aggravate and promote chronic diseases already associated with inflammation. The purpose of this narrative review was to highlight current knowledge with respect to specific podocyte DAMPs and pattern recognition receptors and to provide insight into ongoing work and possible future research avenues to advance our understanding of podocyte immune mechanisms.

中文翻译：

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足细胞中的损伤相关分子模式和模式识别受体。


足细胞具有免疫系统成分，允许对内源性和外源性刺激产生各种先天反应。最近，一些小组将不适当的先天免疫信号转导与足细胞损伤联系起来，尤其是慢性、持续性损伤;然而，足细胞的免疫能力尚未完全阐明。损伤相关分子模式 （DAMP） 是从受损细胞（包括足细胞）释放的内源性危险分子，可以引起炎症反应并将免疫细胞募集到损伤区域。这是通过与模式识别受体结合来实现的。最近的证据表明，通过 DAMP 通路的信号传导在很大程度上被认为具有保护作用并对损伤或感染做出反应，可以加重和促进已经与炎症相关的慢性疾病。本叙述性综述的目的是强调当前关于特定足细胞 DAMP 和模式识别受体的知识，并提供对正在进行的工作和未来可能的研究途径的见解，以促进我们对足细胞免疫机制的理解。