Coordination polymers (CPs) and metal–organic frameworks (MOFs) constitute a new class of antibacterial materials. Interest in them stems from their wide range of topology, dimensionality, and secondary building units that can be tuned by an appropriate choice of metal ions and ligands. In particular, silver-based species feature good antibacterial properties. In this study, we explored the coordination of three acetylenic dithioether RSCH₂C≡CCH₂SR [R = phenyl (L_Ph), cyclohexyl (L_Cy), or tert-butyl (L_tBu)] ligands on several silver salts (silver tosylate, silver triflate, and silver trifluoroacetate). The crystallographic characterization evidenced the formation of a molecular macrocycle and six CPs with different dimensionalities, ranging from one to two dimensions. In most cases, they are composed of four-coordinated silver atoms in a tetrahedral environment. Their antibacterial activity was investigated against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. All CPs present good antibacterial properties against the tested bacteria with minimal inhibitory concentrations ranging from 5 to 40 μg of Ag/mL. Interestingly, we found that these values could not be correlated to their architecture or morphology or to the amount of silver released. The cytotoxicity of these compounds was also evaluated on normal human dermal fibroblasts, and three of these CPs were found to be biocompatible.

中文翻译：

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银 （I） 盐上乙炔二硫醚配体的配位组装：晶体结构、抗菌和细胞毒性活性


配位聚合物 （CPs） 和金属有机框架 （MOF） 构成了一类新的抗菌材料。对它们的兴趣源于它们广泛的拓扑结构、维度和二级建筑单元，可以通过适当选择金属离子和配体来调整。特别是，银基物种具有良好的抗菌性能。在这项研究中，我们探讨了三种乙炔二硫醚 RSCH₂C≡CCH₂SR [R = 苯基 （L_Ph）、环己基 （L_Cy） 或叔丁基 （L_tBu）] 配体在几种银盐（甲苯磺酸银、三氟磺酸银和三氟乙酸银）上的配位。晶体学表征证明了一个分子大环和六个不同维度（从一维到二维）的 CP 的形成。在大多数情况下，它们由四面体环境中的四个配位银原子组成。研究了它们对革兰氏阳性 （金黄色葡萄球菌） 和革兰氏阴性 （大肠杆菌） 细菌的抗菌活性。所有 CP 对测试细菌均具有良好的抗菌性能，最小抑制浓度范围为 5 至 40 μg Ag/mL。有趣的是，我们发现这些值与它们的结构或形态或释放的银量无关。还在正常人真皮成纤维细胞上评估了这些化合物的细胞毒性，发现其中三种 CP 具有生物相容性。