BACKGROUND Exposomics, the study of the exposome, is flourishing, but the field is not well defined. The term "exposome" refers to all environmental influences and associated biological responses throughout the lifespan. However, this definition is very similar to that of the term "environment"-the external elements and conditions that surround and affect the life and development of an organism. Consequently, the exposome seems to be nothing more than a synonym for the environment, and exposomics a synonym for environmental research. As a result, some have rebranded their "standard" environmental health research with the neologistic exposome term, whereas others ignore or seek to abandon the seemingly redundant concept of the exposome. OBJECTIVES We argue that exposomics needs to sharpen its mission focus to counteract this apparent redundancy. Exposomics should be defined as a research program in environmental health aimed at enabling a comprehensive and discovery-driven approach to identifying environmental determinants of human health. Similar to the aim of the Human Genome Project, exposomics aims to analyze the complete complexity of exposures and their corresponding biological responses. Exposomics' primary premise is that the existence of undiscovered, potentially interconnected, nongenetic (environmental) risk factors for health necessitates a comprehensive discovery-driven analysis approach. DISCUSSION We argue that exposomics researchers should adopt our reconceptualization of exposomics and focus on the productiveness and integrity of their research program: its purpose and principles. We suggest that exposomics researchers should coordinate the writing of reviews that assess the program's productiveness and integrity, as well as provide a platform for exposomics researchers to define their vision for the field. https://doi.org/10.1289/EHP14509.

中文翻译：

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重新概念化和定义环境健康中的暴露组学：扩大健康研究的范围。


背景技术暴露组学，即暴露组的研究，正在蓬勃发展，但该领域尚未明确界定。术语“暴露组”是指整个生命周期中所有环境影响和相关的生物反应。然而，这个定义与“环境”一词非常相似——围绕并影响有机体生命和发育的外部元素和条件。因此，暴露组似乎只不过是环境的同义词，而暴露组学则是环境研究的同义词。因此，一些人用新的暴露组术语重新命名了他们的“标准”环境健康研究，而另一些人则忽视或试图放弃看似多余的暴露组概念。目标 我们认为，暴露组学需要加强其任务重点，以抵消这种明显的冗余。暴露组学应被定义为环境健康方面的一项研究计划，旨在采用全面的、以发现为驱动的方法来确定人类健康的环境决定因素。与人类基因组计划的目标类似，暴露组学旨在分析暴露的完整复杂性及其相应的生物反应。暴露组学的主要前提是，尚未发现的、潜在相互关联的、非遗传（环境）健康风险因素的存在需要一种全面的发现驱动的分析方法。讨论 我们认为，暴露组学研究人员应该采用我们对暴露组学的重新概念化，并关注其研究计划的生产力和完整性：其目的和原则。 我们建议暴露组学研究人员应该协调评估该计划的生产力和完整性的评论的撰写，并为暴露组学研究人员提供一个平台来定义他们对该领域的愿景。 https://doi.org/10.1289/EHP14509。