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Interaction of retinal electrophysiology and novel orthokeratology lens use on myopia control efficacy in children
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2024-09-27 , DOI: 10.1136/bjo-2023-324347 Kai Yip Choi, Gigi Tsz King Wong, Sonia Seen Hang Chan, Thomas Chuen Lam, Henry Ho-lung Chan
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2024-09-27 , DOI: 10.1136/bjo-2023-324347 Kai Yip Choi, Gigi Tsz King Wong, Sonia Seen Hang Chan, Thomas Chuen Lam, Henry Ho-lung Chan
Aims The relationship between retinal electrophysiological function and myopia progression was evaluated in school-aged children wearing Breath-O-Correct Orthokeratology (OK) lenses compared with those wearing single vision (SV) lenses over 24 months. Methods In this randomised, single-blind, parallel controlled trial, children aged 8–12 years with −1.00 to −4.00 D of myopia were recruited. Retinal function was evaluated using global-flash multifocal electroretinography at baseline before OK or SV treatment. Axial length was evaluated at 6-month intervals up to 24 months. The main outcome measures were axial elongation (AE) between groups and the interactive effect of baseline retinal function. Results A total of 70 children (43 OK, 9.8±1.3 years; 27 SV, 9.5±1.4 years) completed the 2-year study and were included in the analysis. The 2-year normalised AE was 0.37±0.37 mm in the OK group and 0.60±0.41 mm in the SV group, respectively. For children in the SV group, the amplitude of the central inner retinal response was negatively correlated with axial length elongation (p=0.03). In contrast, this relationship between retinal electrophysiology and AE was not observed in OK group, indicating that they were independent of each other in children treated with OK (p=0.33). Conclusion A weak retinal electrophysiological response was a risk factor for rapid AE in SV controls. However, OK treatment can lower this risk factor and significantly reduce AE in school-aged children. Data are available upon reasonable request. The data that support the findings of this study are available from the corresponding author upon reasonable request.
中文翻译:
视网膜电生理学与新型角膜塑形镜的相互作用对儿童近视控制效果的影响
目的 与佩戴单光 (SV) 镜片超过 24 个月的学龄儿童相比,评估佩戴呼吸 O 型角膜塑形镜 (OK) 镜片的学龄儿童的视网膜电生理功能与近视进展之间的关系。方法 在这项随机、单盲、平行对照试验中,招募了近视度数为-1.00 至-4.00 D 的8-12 岁儿童。在 OK 或 SV 治疗之前,在基线时使用全局闪光多焦视网膜电图评估视网膜功能。每 6 个月至 24 个月评估眼轴长度。主要结果指标是组间的眼轴伸长(AE)和基线视网膜功能的交互作用。结果 共有 70 名儿童(43 名 OK,9.8±1.3 岁;27 名 SV,9.5±1.4 岁)完成了为期 2 年的研究并纳入分析。 OK 组和 SV 组的 2 年标准化 AE 分别为 0.37±0.37 mm 和 0.60±0.41 mm。对于SV组的儿童,中央视网膜内反应的幅度与眼轴伸长呈负相关(p=0.03)。相反,在 OK 组中未观察到视网膜电生理学与 AE 之间的这种关系,表明在接受 OK 治疗的儿童中它们是相互独立的(p=0.33)。结论 视网膜电生理反应较弱是 SV 对照组快速发生 AE 的危险因素。然而,OK 治疗可以降低这一危险因素,并显着减少学龄儿童的 AE。数据可根据合理要求提供。支持本研究结果的数据可根据合理要求从通讯作者处获得。
更新日期:2024-09-28
中文翻译:
视网膜电生理学与新型角膜塑形镜的相互作用对儿童近视控制效果的影响
目的 与佩戴单光 (SV) 镜片超过 24 个月的学龄儿童相比,评估佩戴呼吸 O 型角膜塑形镜 (OK) 镜片的学龄儿童的视网膜电生理功能与近视进展之间的关系。方法 在这项随机、单盲、平行对照试验中,招募了近视度数为-1.00 至-4.00 D 的8-12 岁儿童。在 OK 或 SV 治疗之前,在基线时使用全局闪光多焦视网膜电图评估视网膜功能。每 6 个月至 24 个月评估眼轴长度。主要结果指标是组间的眼轴伸长(AE)和基线视网膜功能的交互作用。结果 共有 70 名儿童(43 名 OK,9.8±1.3 岁;27 名 SV,9.5±1.4 岁)完成了为期 2 年的研究并纳入分析。 OK 组和 SV 组的 2 年标准化 AE 分别为 0.37±0.37 mm 和 0.60±0.41 mm。对于SV组的儿童,中央视网膜内反应的幅度与眼轴伸长呈负相关(p=0.03)。相反,在 OK 组中未观察到视网膜电生理学与 AE 之间的这种关系,表明在接受 OK 治疗的儿童中它们是相互独立的(p=0.33)。结论 视网膜电生理反应较弱是 SV 对照组快速发生 AE 的危险因素。然而,OK 治疗可以降低这一危险因素,并显着减少学龄儿童的 AE。数据可根据合理要求提供。支持本研究结果的数据可根据合理要求从通讯作者处获得。