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The Protective Potential of Butyrate against Colon Cancer Cell Migration and Invasion Is Critically Dependent on Cell Type
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-09-27 , DOI: 10.1002/mnfr.202400421
Sema Oncel, Bryan D. Safratowich, Huawei Zeng

Short-chain fatty acids such as butyrate are produced through the fermentation of dietary fiber by colonic bacteria. Preclinical studies indicate an anticancer potential of butyrate, but clinical evidence shows greater variability. The study hypothesizes the effectiveness of butyrate on reducing colon cancer cell migration and invasion may vary due to the cell-type.

中文翻译:


丁酸盐对结肠癌细胞迁移和侵袭的保护潜力在很大程度上取决于细胞类型



丁酸盐等短链脂肪酸是通过结肠细菌发酵膳食纤维产生的。临床前研究表明丁酸盐具有抗癌潜力,但临床证据表明差异更大。该研究假设丁酸盐对减少结肠癌细胞迁移和侵袭的有效性可能因细胞类型而异。
更新日期:2024-09-27
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