Bartonella quintana infection is rarely described to be transmitted through solid organ transplant (SOT). We report a cluster of using donor-derived B quintana infection and the attack rate from Bartonella seropositive donors. In this retrospective study of SOT recipients that received an organ from an unhoused deceased donor (UDD) in Alberta in 2022-2023, serology testing for Bartonella was performed indirect immunofluorescent assay on UDDs and recipients of UDDs with positive serology. Titers ≥1:64 were considered positive. During the study period, 31/32 UDDs were tested for immunoglobulin G to Bartonella (20 negative, 11 positive for B quintana and/or B henselae). Thirty-two organs were transplanted from the 11 seropositive donors. Six SOT recipients developed bartonellosis secondary to B quintana (4 SOT recipients received organs from 3 seropositive donors, and 2 SOT recipients from 1 UDD with no stored sample for testing). The attack rate for clinical disease from positive donors was 12.5% (4/32). The main presentation was skin nodules/papules (median 5.5 months) with bacillary angiomatosis in 4/6. Bartonella serology was positive in 5/6 SOT recipients (initially negative in 2) and blood B quintana quantitative polymerase chain reaction in 1. None had visceral involvement. All donors had history of substance use. This outbreak of bartonellosis reinforces the potential for unexpected donor-transmitted infections. Clinicians should be aware of high transmission of B quintana through transplant from infected UDDs.

中文翻译：

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阿尔伯塔省无家可归供体的实体器官移植受者的供体来源的巴尔通体病


五日热巴尔通体感染很少被描述为通过实体器官移植 （SOT） 传播。我们报告了一组使用供体来源的五日热巴尔通体感染和巴尔通体血清阳性供体的发病率。在这项回顾性研究中，对 2022-2023 年阿尔伯塔省无家可归的已故供体 （UDD） 接受者的器官进行了回顾性研究，对 UDD 和血清学阳性的 UDD 接受者进行了巴尔通体血清学检测。滴度 ≥1：64 被认为是阳性的。在研究期间，对 31/32 个 UDD 进行了针对巴尔通体的免疫球蛋白 G 检测 （20 个阴性，11 个五日热巴尔通体和/或汉赛巴尔通体阳性）。从 11 名血清阳性供体中移植了 32 个器官。6 名 SOT 受者出现继发于五日热巴尔通体的巴尔通体病 （4 名 SOT 受者接受了 3 名血清阳性供体的器官，2 名 SOT 受者接受了 1 名 UDD 的器官，没有储存样本进行检测）。阳性供体对临床疾病的发病率为 12.5% （4/32）。主要表现为皮肤结节/丘疹 （中位 5.5 个月），伴有 4/6 的细菌性血管瘤病。5/6 例 SOT 受者巴尔通体血清学阳性（2 例最初为阴性），1 例血 B 五日热定量聚合酶链反应。没有人有本能的参与。所有供体都有物质使用史。巴尔通体病的暴发加强了供体意外传播感染的可能性。临床医生应注意五日热巴尔通体通过受感染 UDD 移植的高传播率。