To evaluate oocyte cryopreservation among transgender and gender-diverse adolescents and young adults with or without prior testosterone exposure, we performed a retrospective cohort study of all patients younger than age 35 years referred for oocyte cryopreservation through our formal fertility-preservation program from 2014 to 2023. The number of patients referred and pursuing fertility preservation increased over time. Among the 93 patients referred, 37 pursued oocyte cryopreservation (31 testosterone-naïve and six testosterone-exposed). Among the latter, neither length of time on testosterone before presentation nor duration off testosterone before retrieval (minimum 2 months) were associated with the number of mature oocytes frozen. When comparing testosterone-naïve with testosterone-exposed individuals, there was no difference in number of oocytes retrieved (median 28 vs 32, P=0.43) or mature oocytes frozen (21 vs 21, P=0.95).

中文翻译：

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先前使用或未使用睾酮的跨性别和性别多样化个体的卵母细胞冷冻保存。


为了评估跨性别和性别多样化的青少年和年轻人（无论是否曾接触过睾酮）的卵母细胞冷冻保存情况，我们对 2014 年至 2023 年通过我们的正式生育力保存计划转介进行卵母细胞冷冻保存的所有 35 岁以下患者进行了回顾性队列研究随着时间的推移，转诊并寻求保留生育能力的患者数量不断增加。在转诊的 93 名患者中，37 名患者进行了卵母细胞冷冻保存（31 名患者未接受过睾酮治疗，6 名患者接受过睾酮治疗）。在后者中，出现前服用睾酮的时间长度和取出前停用睾酮的时间（至少 2 个月）均与冷冻成熟卵母细胞的数量无关。当比较未接受过睾酮的个体与暴露于睾酮的个体时，回收的卵母细胞数量（中位数 28 vs 32，P=0.43）或冷冻成熟卵母细胞的数量（21 vs 21，P=0.95）没有差异。