Infants aged <6 months are at increased risk for severe COVID-19 disease but are not yet eligible for COVID-19 vaccination; these children depend upon transplacental transfer of maternal antibody, either from vaccination or infection, for protection. COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) data were analyzed to estimate COVID-19-associated hospitalization rates and identify demographic and clinical characteristics and maternal vaccination status of infants aged <6 months hospitalized with laboratory-confirmed COVID-19. During October 2022-April 2024, COVID-NET identified 1,470 COVID-19-associated hospitalizations among infants aged <6 months. COVID-19-associated hospitalization rates among young infants were higher than rates among any other age group, except adults aged ≥75 years, and are comparable to rates among adults aged 65-74 years. The percentage of hospitalized infants whose mothers had been vaccinated during pregnancy was 18% during October 2022-September 2023 and decreased to <5% during October 2023-April 2024. Severe outcomes among infants hospitalized with COVID-19 occurred frequently: excluding newborns hospitalized at birth, approximately one in five young infants hospitalized with COVID-19 required admission to an intensive care unit, nearly one in 20 required mechanical ventilation, and nine infants died during their COVID-19-associated hospitalization. To help protect pregnant persons and infants too young to be vaccinated, prevention for these groups should focus on ensuring that pregnant persons receive recommended COVID-19 vaccines.

中文翻译：

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<6 个月大婴儿的 COVID-19 相关住院和孕产妇疫苗接种 - COVID-NET，12 个州，2022 年 10 月至 2024 年 4 月。


<6 个月大的婴儿患严重 COVID-19 疾病的风险增加，但尚不符合 COVID-19 疫苗接种的条件;这些儿童依靠来自疫苗接种或感染的母体抗体经胎盘转移来获得保护。分析 COVID-19 相关住院监测网络 （COVID-NET） 数据以估计 COVID-19 相关住院率，并确定因实验室确诊的 COVID-19 住院的 <6 个月龄婴儿的人口统计学和临床特征以及母亲疫苗接种状况。在 2022 年 10 月至 2024 年 4 月期间，COVID-NET 在 <6 个月大的婴儿中确定了 1,470 例与 COVID-19 相关的住院治疗。除 75 岁成人外，幼儿与 COVID-19 相关的住院率高于任何其他年龄组≥住院率，与 65-74 岁成人的住院率相当。2022 年 10 月至 2023 年 9 月期间，母亲在怀孕期间接种疫苗的住院婴儿百分比为 18%，在 2023 年 10 月至 2024 年 4 月期间降至 <5%。因 COVID-19 住院的婴儿的严重后果经常发生：不包括出生时住院的新生儿，大约五分之一的因 COVID-19 住院的婴儿需要入住重症监护病房，近 20 名婴儿中有 1 名需要机械通气，9 名婴儿在与 COVID-19 相关的住院治疗期间死亡。为了帮助保护孕妇和年龄太小而无法接种疫苗的婴儿，针对这些群体的预防应侧重于确保孕妇接种推荐的 COVID-19 疫苗。