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Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-09-27 , DOI: 10.1002/mnfr.202400501
Zhaocai Ren, Shang Gao, Shiwei Hu, Sichun Chen, Wei Jiang, Yaming Ge

Previous study has demonstrated the chemical structure of chondroitin sulfate (CHS) from Halaelurus burgeri skin and its effects on insulin resistance. However, the precise impact of this phenomenon on endoplasmic reticulum (ER) stress and inflammation, which contribute to insulin resistance, remains unclear. This study is to investigate the impact of CHS on ER stress, inflammatory response and signaling, and gut microbiota in high-fat diet (HFD)-fed mice.

中文翻译:


来自 Halaelurus burgeri 皮肤的硫酸软骨素抑制肝脏内质网应激和炎症,并调节肠道菌群



以前的研究表明,来自 Halaelurus burgeri 皮肤的硫酸软骨素 (CHS) 的化学结构及其对胰岛素抵抗的影响。然而,这种现象对导致胰岛素抵抗的内质网 (ER) 应激和炎症的确切影响尚不清楚。本研究旨在调查 CHS 对高脂饮食 (HFD) 喂养小鼠的 ER 应激、炎症反应和信号传导以及肠道菌群的影响。
更新日期:2024-09-27
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