Here, we show particle size-dependent therapeutic efficacy with a Zn-based metal–organic framework (MOF). The size of MOFs was tuned in specific ranges (∼100, 200, and 300 nm) built upon the manipulation of synthetic conditions. X-ray photoelectron spectroscopy, infrared, PXRD, and dynamic light scattering and scanning electron microscopy analyses were used to identify the synthesized structures. The various analyses revealed minimal changes in the molecular properties of these structures regardless of their size, confirming our hypothesis regarding the preservation of the identity of MOF nanoparticles despite size variation. The synthesized carriers undergo structure relative destruction in response to a weak acidic tumor microenvironment, and this relative degradation allows the release of the Nimesulide drug into the environment. Interestingly, anticancer studies resulting in SKBR3 (Human breast cancer cell) cells indicate that the different sizes resulted in various inhibition capacities against cancer cells. This work shows the importance of optimizing the geometry of the drug carrier, such as size and shape, to achieve the highest cellular uptake and therapeutic performance. Besides, theoretical studies were carried out using B3LYP/6-31G (d,p) and density functional theory methods to more consider the drug adsorption mechanism.

中文翻译：

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研究金属有机框架在药物输送和抗癌特性中的尺寸效应


在这里，我们展示了基于锌的金属有机框架（MOF）的粒径依赖性治疗功效。 MOF 的尺寸根据合成条件的控制调整在特定范围（~100、200 和 300 nm）。 X射线光电子能谱、红外、PXRD、动态光散射和扫描电子显微镜分析用于鉴定合成的结构。各种分析表明，无论这些结构的大小如何，其分子特性的变化都很小，这证实了我们关于尽管大小变化但仍能保持 MOF 纳米粒子特性的假设。合成的载体响应弱酸性肿瘤微环境而经历结构相对破坏，并且这种相对降解允许尼美舒利药物释放到环境中。有趣的是，针对 SKBR3（人乳腺癌细胞）细胞的抗癌研究表明，不同大小的细胞对癌细胞的抑制能力不同。这项工作表明了优化药物载体的几何形状（例如尺寸和形状）以实现最高的细胞摄取和治疗性能的重要性。此外，利用B3LYP/6-31G(d,p)和密度泛函理论方法进行理论研究，更多地考虑药物吸附机制。