The cutaneous lymphatic system regulates tissue inflammation, fluid balance and immunological responses. Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema, immune deficiency, chronic inflammation etc. Tissue regeneration and healing depend on angiogenesis and lymphangiogenesis during wound healing. Tissue oedema and chronic inflammation can slow wound healing due to impaired lymphangiogenesis or lymphatic dysfunction. For example, impaired lymphangiogenesis or lymphatic dysfunction has been detected in nonhealing wounds such as diabetic ulcers, venous ulcers and bedsores. This review summarizes the structure and function of the cutaneous lymphatic vessel system and lymphangiogenesis in wounds. Furthermore, we review wound lymphangiogenesis processes and remodelling, especially the influence of the inflammatory phase. Finally, we outline how to control lymphangiogenesis to promote wound healing, assess the possibility of targeting lymphangiogenesis as a novel treatment strategy for chronic wounds and provide an analysis of the possible problems that need to be addressed.

中文翻译：

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淋巴管生成：促进皮肤伤口愈合的新策略


皮肤淋巴系统调节组织炎症、体液平衡和免疫反应。淋巴管生成或淋巴管功能障碍可能导致淋巴水肿、免疫缺陷、慢性炎症等。伤口愈合过程中组织的再生和愈合依赖于血管生成和淋巴管生成。由于淋巴管生成受损或淋巴功能障碍，组织水肿和慢性炎症会减慢伤口愈合。例如，在糖尿病性溃疡、静脉性溃疡和褥疮等不愈合伤口中发现了受损的淋巴管生成或淋巴功能障碍。本综述总结了皮肤淋巴管系统的结构和功能以及伤口中的淋巴管生成。此外，我们回顾了伤口淋巴管生成过程和重塑，特别是炎症阶段的影响。最后，我们概述了如何控制淋巴管生成以促进伤口愈合，评估将淋巴管生成作为慢性伤口新治疗策略的可能性，并对需要解决的可能问题进行分析。