The recent capability to measure thousands of plasma proteins from a tiny blood sample has provided a new dimension of expansive data that can advance our understanding of human health. For example, the company SomaLogic has developed the means to measure more than 10,000 proteins and Thermo Fisher’s Olink assays over 5400 proteins from as little as 2 μl. When these rich data are integrated with other layers of information from large patient cohorts, such as the UK Biobank’s genetic, health, and lifestyle information from half a million participants, we get new insights about the underpinnings of disease, the aging process, and the potential ability to forecast an individual’s health trajectory.

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高通量蛋白质组学和 AI 的革命


最近能够从微小的血液样本中测量数千种血浆蛋白，这为广泛的数据提供了一个新的维度，可以促进我们对人类健康的了解。例如，SomaLogic 公司开发了测量 10,000 多种蛋白质的方法，而 Thermo Fisher 的 Olink 分析方法则从低至 2 μl 的 5400 多种蛋白质中检测。当这些丰富的数据与来自大型患者群体的其他层次信息相结合时，例如来自五十万参与者的英国生物样本库的遗传、健康和生活方式信息，我们可以获得有关疾病基础、衰老过程以及预测个人健康轨迹的潜在能力的新见解。