Objective To evaluate radiographic knee osteoarthritis (OA) progression, development of knee OA, patient-reported outcomes and knee muscle strength at 10-year follow-up after arthroscopic partial meniscectomy (APM) or exercise therapy for degenerative meniscal tears. Methods Randomised controlled trial including 140 participants, with a degenerative meniscal tear and no or minimal radiographic OA changes. Participants were randomised to either APM or 12 weeks of exercise therapy (1:1 ratio). The primary outcome was knee OA progression assessed by the Osteoarthritis Research Society International (OARSI) atlas sum score (sum of medial and lateral compartment joint space narrowing and osteophyte score). Secondary outcomes included incidence of radiographic and symptomatic knee OA, patient-reported pain and knee function and isokinetic knee muscle strength. Results The adjusted mean difference in change in the OARSI sum score was 0.39 (95% CI −0.19 to 0.97), with more progression in the APM group. The incidence of radiographic knee OA was 23% in the APM group and 20% in the exercise group (adjusted risk difference 3% (95% CI −13% to 19%)). No clinically relevant differences were found in patient-reported outcomes or isokinetic knee muscle strength. Conclusion No differences in radiographic knee OA progression and comparable rates of knee OA development were observed 10 years following APM and exercise therapy for degenerative meniscal tears. Both treatments were associated with improved patient-reported pain and knee function. Trial registration number [NCT01002794][1]. Data are available on reasonable request. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01002794&atom=%2Fbjsports%2Fearly%2F2024%2F09%2F26%2Fbjsports-2024-108644.atom

中文翻译：

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关节镜下部分半月板切除术与运动疗法治疗退行性半月板撕裂：OMEX 随机对照试验的 10 年随访


目的 评估关节镜部分半月板切除术 (APM) 或退行性半月板撕裂运动治疗后 10 年随访时的放射学膝骨关节炎 (OA) 进展、膝关节 OA 的发展、患者报告的结果和膝关节肌肉强度。方法 随机对照试验包括 140 名受试者，受试者患有退行性半月板撕裂，且放射学 OA 没有变化或仅有极少变化。参与者被随机分配接受 APM 或 12 周的运动治疗（1:1 比例）。主要结局是通过国际骨关节炎研究协会 (OARSI) 图集总评分（内侧和外侧间隔关节间隙狭窄和骨赘评分的总和）评估膝关节 OA 进展。次要结局包括放射学和症状性膝关节 OA 的发生率、患者报告的疼痛和膝关节功能以及等速膝关节肌力。结果 OARSI 总分变化的调整后平均差异为 0.39（95% CI -0.19 至 0.97），APM 组进展较多。放射学膝关节 OA 的发生率在 APM 组中为 23%，在运动组中为 20%（调整后的风险差异为 3%（95% CI -13% 至 19%））。在患者报告的结果或等速膝盖肌肉力量方面没有发现临床相关的差异。结论 APM 和运动疗法治疗退行性半月板撕裂 10 年后，放射学膝关节 OA 进展情况和膝关节 OA 发生率没有差异。两种治疗均与患者报告的疼痛和膝关节功能的改善相关。试验注册号[NCT01002794][1]。可根据合理要求提供数据。 [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01002794&atom=%2Fbjsports%2Fearly%2F2024%2F09%2F26%2Fbjsports-2024-108644.atom