NF-Y is a conserved sequence-specific trimeric Transcription Factor -TF- binding to the CCAAT element. We review here the role(s) in development, from pre-implantation embryo to terminally differentiated tissues, by rationalizing and commenting on genetic, genomic, epigenetic and biochemical studies. This effort brings to light the impact of NF-YA isoforms on stemness and differentiation, as well as binding to distal vs promoter proximal sites and connections with selected TFs.

中文翻译：

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NF-Y 在发育和分化中的作用

NF-Y 是与 CCAAT 元件结合的保守序列特异性三聚体转录因子 -TF-。我们通过对遗传、基因组、表观遗传和生化研究的合理化和评论，回顾了从植入前胚胎到终末分化组织的发育中的作用。这项工作揭示了 NF-YA 同工型对干性和分化的影响，以及与远端与启动子近端位点的结合以及与选定 TF 连接的影响。