BACKGROUND Achievement of guideline-recommended levels of physical activity (≥150 minutes of moderate-to-vigorous physical activity per week) is associated with lower risk of adverse cardiovascular events and represents an important public health priority. Although physical activity commonly follows a "weekend warrior" pattern, in which most moderate-to-vigorous physical activity is concentrated in 1 or 2 days rather than spread more evenly across the week (regular), the effects of physical activity pattern across a range of incident diseases, including cardiometabolic conditions, are unknown. METHODS We tested associations between physical activity pattern and incidence of 678 conditions in 89 573 participants (62±8 years of age; 56% women) of the UK Biobank prospective cohort study who wore an accelerometer for 1 week between June 2013 and December 2015. Models were adjusted for multiple baseline clinical factors, and P value thresholds were corrected for multiplicity. RESULTS When compared to inactive (<150 minutes moderate-to-vigorous physical activity/week), both weekend warrior (267 total associations; 264 [99%] with lower disease risk; hazard ratio [HR] range, 0.35-0.89) and regular activity (209 associations; 205 [98%] with lower disease risk; HR range, 0.41-0.88) were broadly associated with lower risk of incident disease. The strongest associations were observed for cardiometabolic conditions such as incident hypertension (weekend warrior: HR, 0.77 [95% CI, 0.73-0.80]; P=1.2×10-27; regular: HR, 0.72 [95% CI, 0.68-0.77]; P=4.5×10-28), diabetes (weekend warrior: HR, 0.57 [95% CI, 0.51-0.62]; P=3.9×10-32; regular: HR, 0.54 [95% CI, 0.48-0.60]; P=8.7×10-26), obesity (weekend warrior: HR, 0.55 [95% CI, 0.50-0.60]; P=2.4×10-43, regular: HR, 0.44 [95% CI, 0.40-0.50]; P=9.6×10-47), and sleep apnea (weekend warrior: HR, 0.57 [95% CI, 0.48-0.69]; P=1.6×10-9; regular: HR, 0.49 [95% CI, 0.39-0.62]; P=7.4×10-10). When weekend warrior and regular activity were compared directly, there were no conditions for which effects differed significantly. Observations were similar when activity was thresholded at the sample median (≥230.4 minutes of moderate-to-vigorous physical activity/week). CONCLUSIONS Achievement of measured physical activity volumes consistent with guideline recommendations is associated with lower risk for >200 diseases, with prominent effects on cardiometabolic conditions. Associations appear similar whether physical activity follows a weekend warrior pattern or is spread more evenly throughout the week.

中文翻译：

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“周末勇士”体育活动与新发疾病和心脏代谢健康的关联。


背景 达到指南推荐的体育活动水平（每周 ≥150 分钟的中等至剧烈体育活动）与不良心血管事件的风险降低相关，是重要的公共卫生优先事项。尽管身体活动通常遵循“周末战士”模式，其中大多数中等到剧烈的体育活动集中在 1 或 2 天内，而不是更均匀地分布在一周内（常规），但身体活动模式对一系列新发疾病（包括心脏代谢状况）的影响尚不清楚。方法 我们测试了英国生物样本库前瞻性队列研究的 89 573 名参与者 （62±8 岁;56% 为女性） 的身体活动模式与 678 种疾病发生率之间的关联，这些参与者在 2013 年 6 月至 2015 年 12 月期间佩戴加速度计 1 周。根据多个基线临床因素调整模型，并针对多重性校正 P 值阈值。结果 与不活动（x3C150 分钟中度至剧烈体力活动/周）相比，周末勇士（共 267 个关联;264 [99%] 疾病风险较低;风险比 [HR] 范围，0.35-0.89）和定期活动（209 个关联;205 [98%] 疾病风险较低;HR 范围，0.41-0.88）与较低的发病风险广泛相关。观察到与心脏代谢状况（如高血压）的相关性最强（周末勇士：HR，0.77 [95% CI，0.73-0.80];P=1.2×10-27;常规：HR，0.72 [95% CI，0.68-0.77];P=4.5×10-28）、糖尿病 （周末勇士：HR，0.57 [95% CI，0.51-0.62];P=3.9×10-32;常规：HR，0.54 [95% CI，0.48-0.60];P=8.7×10-26）、肥胖 （周末勇士：HR，0.55 [95% CI，0.50-0.60];P=2.4×10-43，常规：HR，0.44 [95% CI，0.40-0。50];P=9.6×10-47）和睡眠呼吸暂停（周末勇士：HR，0.57 [95% CI，0.48-0.69];P=1.6×10-9;常规：HR，0.49 [95% CI，0.39-0.62];P=7.4×10-10）。当直接比较周末勇士和常规活动时，没有效果差异显著的情况。当在样本中位数（≥230.4 分钟的中度至剧烈身体活动/周）对活动进行阈值时，观察结果相似。结论 达到与指南建议一致的测量体力活动量与降低 >200 疾病的风险相关，对心脏代谢状况有显着影响。无论身体活动是遵循周末勇士模式还是一周内分布更均匀，关联都显得相似。