N6-methyladenosine (m6A) is the most abundant chemical modification in mRNA and plays important roles in human and mouse embryonic stem cell pluripotency, maintenance, and differentiation. We have recently reported that m6A is involved in the postnatal control of β-cell function in physiological states and in type 1 and 2 diabetes. However, the precise mechanisms by which m6A acts to regulate the development of human and mouse pancreas are unexplored. Here, we show that the m6A landscape is dynamic during human pancreas development, and that METTL14, one of the m6A writer complex proteins, is essential for the early differentiation of both human and mouse pancreatic cells.

中文翻译：

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METTL14 的 m6A mRNA 甲基化调节早期胰腺细胞分化。


N6-甲基腺苷 （m6A） 是 mRNA 中最丰富的化学修饰，在人和小鼠胚胎干细胞的多能性、维持和分化中起重要作用。我们最近报道了 m6A 参与生理状态下 β 细胞功能的出生后控制以及 1 型和 2 型糖尿病。然而，m6A 调节人和小鼠胰腺发育的确切机制尚未得到探索。在这里，我们表明 m6A 景观在人类胰腺发育过程中是动态的，并且 METTL14 是 m6A 写入复合蛋白之一，对于人和小鼠胰腺细胞的早期分化至关重要。