Mesenchymal stem cells (MSC) have immune regulatory properties that may ameliorate pathophysiological processes in sepsis. We determined the effect of allogeneic adipose-derived MSCs (Cx611) on the host response during sepsis due to community-acquired bacterial pneumonia (CABP) by measuring 29 plasma biomarkers and blood transcriptomes at six time points in 82 patients randomised to two intravenous infusions of Cx611 or placebo. Cx611 treatment enhanced several endothelial cell and procoagulant response plasma biomarkers, and led to increased expression of pathways related to innate immunity, haemostasis and apoptosis. Cx611 infusion in sepsis due to CABP is associated with broad host response alterations. RNAseq data are available from the NCBI Sequence Read Archive (SRA) under the BioProject accession PRJNA1097551. Other data generated and/or analysed during the current study are available on reasonable request.

中文翻译：

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间充质干细胞对重症社区获得性肺炎宿主反应的影响


间充质干细胞 （MSC） 具有免疫调节特性，可以改善脓毒症的病理生理过程。我们通过测量 82 名随机接受两次静脉输注 Cx611 或安慰剂的患者在 6 个时间点的 29 种血浆生物标志物和血液转录组，确定了同种异体脂肪来源的 MSC （Cx611） 对社区获得性细菌性肺炎 （CABP） 引起的脓毒症期间宿主反应的影响。Cx611 治疗增强了几种内皮细胞和促凝反应血浆生物标志物，并导致与先天免疫、止血和细胞凋亡相关的通路表达增加。CABP 引起的脓毒症中输注 Cx611 与广泛的宿主反应改变有关。RNAseq 数据可从 BioProject 登录PRJNA1097551下的 NCBI 序列读取档案 （SRA） 中获得。在当前研究期间生成和/或分析的其他数据可应合理要求提供。