Interstitial lung disease (ILD) is a heterogeneous parenchymal disorder.1 2 Patients with ILD often present with non-specific symptoms such as a non-productive cough and exertional dyspnoea. The differential diagnosis for ILD is broad and includes conditions such as connective tissue disease (CTD), hypersensitivity pneumonitis, drug-associated ILD and granulomatous diseases. Furthermore, the initial management depends on factors such as antigen exposure, causative drugs, inflammation and fibrosis. Accurate diagnosis requires a detailed medical history, chest high-resolution CT (HRCT) and pathology.3 4 From a physiological perspective, ILD manifests as a restrictive disorder with reduced diffusion capacity of the lungs for carbon monoxide (DLco).5–7 Many clinical trials on ILD have used forced vital capacity (FVC) as a surrogate marker for mortality.8 9 Additionally, trends in FVC and DLco have been shown to be useful predictors of mortality, particularly in idiopathic pulmonary fibrosis (IPF).10 11 In the management and prognosis of ILD, pulmonary function tests (PFT), including FVC and DLco, are crucial physiological indices.12–14 It is important to note that height, …

中文翻译：

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全球肺功能倡议 （GLI） 对 ILD 的效用的编辑


间质性肺病 （ILD） 是一种异质性实质疾病1 2 ILD 患者通常表现为非特异性症状，例如干咳和劳力性呼吸困难。ILD 的鉴别诊断范围很广，包括结缔组织病 （CTD）、过敏性肺炎、药物相关 ILD 和肉芽肿病等疾病。此外，初始管理取决于抗原暴露、致病药物、炎症和纤维化等因素。准确诊断需要详细的病史、胸部高分辨率 CT （HRCT） 和病理学检查3 4 从生理学角度来看，ILD 表现为一种限制性疾病，肺部一氧化碳弥散能力 （DLco） 降低5-7 许多关于 ILD 的临床试验都使用用力肺活量 （FVC） 作为死亡率的替代标志物8 9 此外， FVC 和 DLco 的趋势已被证明是死亡率的有用预测指标，尤其是在特发性肺纤维化 （IPF） 中.10 11 在 ILD 的管理和预后中，肺功能测试 （PFT），包括 FVC 和 DLco，是关键的生理指标.12-14 重要的是要注意身高、...