We extend our congratulations to Tevethia et al for their recently published ‘CAVARLY trial’, which suggests the combination of variceal band ligation (VBL) and carvedilol is superior to VBL or carvedilol alone in the reduction of the first episode of oesophageal variceal bleeding (OVB) in patients with high-risk varices.1 This is the first primary prophylaxis randomised control trial to examine combination therapy and provides some interesting results which require further thought. Despite significantly lower rates of OVB and mortality in the combination therapy group, other indicators of disease severity such as; progression of ascites, …

中文翻译：

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静脉曲张套扎术和卡维地洛：永远在一起，还是不在一起？


我们祝贺 Tevethia 等人最近发表的“CAVARLY 试验”，该试验表明静脉曲张套扎术 (VBL) 和卡维地洛联合治疗在减少首次食管静脉曲张出血 (OVB) 方面优于单独使用 VBL 或卡维地洛）在高风险静脉曲张患者中。1这是第一个检查联合治疗的一级预防随机对照试验，并提供了一些需要进一步思考的有趣结果。尽管联合治疗组的 OVB 发生率和死亡率显着降低，但疾病严重程度的其他指标，例如：腹水的进展，...