When dysregulated, skin fibrosis can lead to a multitude of pathologies. We provide a framework for understanding the wide clinical spectrum, mechanisms, and management of cutaneous fibrosis encompassing a variety of matrix disorders, fibrohistiocytic neoplasms, injury-induced scarring, and autoimmune scleroses. Underlying such entities are common mechanistic pathways that leverage morphogenic signaling, immune activation, and mechanotransduction to modulate fibroblast function. In light of the limited array of available treatments for cutaneous fibrosis, scientific insights have opened new therapeutic and investigative avenues for conditions that still lack effective interventions.

中文翻译：

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皮肤纤维化的临床、机制和治疗前景


当失调时，皮肤纤维化会导致多种病症。我们提供了一个框架来了解皮肤纤维化的广泛临床谱、机制和管理，包括各种基质疾病、纤维组织细胞肿瘤、损伤诱导的瘢痕形成和自身免疫性硬化。这些实体的基础是利用形态发生信号传导、免疫激活和机械转导来调节成纤维细胞功能的常见机制通路。鉴于皮肤纤维化的可用治疗方法有限，科学见解为仍然缺乏有效干预措施的疾病开辟了新的治疗和研究途径。