From the known lactone (S)-4, easily derived from L-glutamic acid, a scalable approach to chiral building block O-silylated 3-hydroxypiperidin-2-one 3 and alkaloid 1 was achieved in five and six-steps respectively. The key steps are a chemoselective amidation of lactone-ester 5 and a one-pot reductive borane-decomplexation, N-debenzylation and cyclization.

中文翻译：

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生物碱（S）-3-羟基哌啶-2-酮及其O - TBS保护衍生物的新合成

从容易衍生自L-谷氨酸的已知内酯（S）-4，分别通过五个步骤和六个步骤实现了可扩展的手性结构单元O-甲硅烷基化的3-羟基哌啶-2-酮3和生物碱1的方​​法。关键步骤是内酯5的化学选择性酰胺化反应以及一锅还原硼烷分解，N-脱苄基化和环化反应。