1H-1-Hydroxyquinolin-4-ones represent a broad class of biologically active heterocycles having an exocyclic N,O motif. Electrosynthesis offers direct, highly selective, and sustainable access to 1-hydroxyquinol-4-ones by nitro reduction. A versatile synthetic route starting from easily accessible 2-nitrobenzoic acids was established. The broad applicability of this protocol was demonstrated on 26 examples with up to 93% yield, highlighted by the naturally occurring antibiotics Aurachin C and HQNO. The practicability and technical relevance were underlined by multigram scale electrolysis.

中文翻译：

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1H-1-羟基喹醇-4-酮合成的高选择性电合成，用于多种天然抗生素


1H-1-羟基喹啉-4-酮代表一大类具有外环 N，O 基序的生物活性杂环。电合成通过硝基还原提供了直接、高选择性和可持续的 1-羟基喹啉-4-酮。建立了一种从易于获得的 2-硝基苯甲酸开始的多功能合成路线。该方案的广泛适用性已在 26 个实例上得到证明，产量高达 93%，天然存在的抗生素 Aurachin C 和 HQNO 尤为突出。数克级电解强调了实用性和技术相关性。