BackgroundPrevious studies provided inconsistent associations between diabetes mellitus (DM) and miscarriage, recurrent miscarriage (RM). Therefore, this study aims to evaluate the association between DM and miscarriage, specifically RM, through a meta‐analysis approach.MethodsWe searched for articles published before July 2023 in PubMed and Web of Science databases. STATA 12.0 software was used to compute all the results collected from included studies.ResultsDM was associated with a higher risk of miscarriage, RM (miscarriage: odds ratio [OR]/relative risk [RR] = 1.23, 95% confidence interval [CI] 1.13 to 1.34; RM: OR/RR = 1.73, 95% CI 1.55 to 1.94). T1DM was associated with a higher risk of miscarriage (OR/RR = 1.16, 95% CI 1.07 to 1.26). Similarly, T2DM showed a higher risk of miscarriage (OR/RR = 1.44, 95% CI 1.23 to 1.68). Miscarriage, RM were associated with a higher risk of DM (miscarriage: OR/RR = 1.14, 95% CI 1.08 to 1.19; RM: OR/RR = 1.14, 95% CI 1.08 to 1.20). Furthermore, miscarriage was found to be associated with a higher risk of T2DM (OR/RR = 1.08, 95% CI 1.05 to 1.11).ConclusionIn conclusion, our meta‐analysis findings indicate a significant association between DM and miscarriages as well as RM. As a result, women with a history of miscarriage should consider regular monitoring of their metabolic health as a potential benefit. Nevertheless, it is important to note that further research is needed to validate the results of our study and shed light on the biological mechanisms underlying these associations.

中文翻译：

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糖尿病与流产、复发性流产之间的关联：一项荟萃研究


背景先前的研究提供了糖尿病（DM）与流产、复发性流产（RM）之间不一致的关联。因此，本研究旨在通过荟萃分析方法评估 DM 与流产（特别是 RM）之间的关联。方法我们检索了 PubMed 和 Web of Science 数据库中 2023 年 7 月之前发表的文章。使用 STATA 12.0 软件计算从纳入研究中收集的所有结果。 结果DM 与较高的流产风险 RM 相关（流产：比值比 [OR]/相对风险 [RR] = 1.23，95% 置信区间 [CI] 1.13 至 1.34；RM：OR/RR = 1.73，95% CI 1.55 至 1.94)。 T1DM 与较高的流产风险相关（OR/RR = 1.16，95% CI 1.07 至 1.26）。同样，T2DM 显示出较高的流产风险（OR/RR = 1.44，95% CI 1.23 至 1.68）。流产、RM 与较高的 DM 风险相关（流产：OR/RR = 1.14，95% CI 1.08 至 1.19；RM：OR/RR = 1.14，95% CI 1.08 至 1.20）。此外，流产被发现与 T2DM 的较高风险相关（OR/RR = 1.08，95% CI 1.05 至 1.11）。 结论 总之，我们的荟萃分析结果表明 DM 与流产以及 RM 之间存在显着关联。因此，有流产史的女性应考虑定期监测其代谢健康状况，作为潜在的好处。然而，值得注意的是，需要进一步的研究来验证我们的研究结果并阐明这些关联背后的生物学机制。