Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O,The Journal of Organic Chemistry

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Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2016-11-01 00:00:00 , DOI: 10.1021/acs.joc.6b02097
Atsushi Umehara ₁ , Hirofumi Ueda ₁ , Hidetoshi Tokuyama ₁

Affiliation

A novel condensation reaction of carboxylic acids with various non-nucleophilic N-heterocycles and anilides was developed. The reaction proceeds in the presence of di-tert-butyl dicarbonate (Boc₂O), catalytic 4-(dimethylamino)pyridine (DMAP), and 2,6-lutidine and is applicable to the acylation of a wide range of non-nucleophilic nitrogen compounds, including indoles, pyrroles, pyrazole, carbazole, lactams, oxazolidinones, and anilides with high functional group compatibility. The scope of indoles, carboxylic acids, and anilides was also studied.

中文翻译：

使用Boc ₂ O将羧酸与非亲核性N-杂环和苯胺类化合物缩合

开发了一种新型的羧酸与各种非亲核N-杂环和苯甲酸酯的缩合反应。在二-的存在下该反应进行叔丁基酯（BOC ₂ O），催化4-（二甲氨基）吡啶（DMAP），和2,6-二甲基吡啶，并适用于范围广泛的非亲核的酰化具有高官能团相容性的氮化合物，包括吲哚，吡咯，吡唑，咔唑，内酰胺，恶唑烷酮和苯甲酸酯。还研究了吲哚，羧酸和苯胺的范围。

更新日期：2016-11-01

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