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Safety and efficacy of rodatristat ethyl for the treatment of pulmonary arterial hypertension (ELEVATE-2): a dose-ranging, randomised, multicentre, phase 2b trial
The Lancet Respiratory Medicine ( IF 38.7 ) Pub Date : 2024-09-19 , DOI: 10.1016/s2213-2600(24)00226-1 Prof Olivier Sitbon PhD, Andris Skride PhD, Jeremy Feldman MD, Sandeep Sahay MD, Oksana A Shlobin MD, Vallerie McLaughlin MD, Hossein-Ardeschir Ghofrani MD, David Langleben MD, Ed Parsley DO, Gwyn D'Souza MD, Tonya Marmon DrPH, Watiri Kamau-Kelley BS, Renee Jones BS, Ravi Grewal MSHS, Steve Wring PhD, Michelle Palacios PhD, Himanshu Naik PhD, Jill Denning MA, Howard M Lazarus MD, Prof Marc Humbert PhD
The Lancet Respiratory Medicine ( IF 38.7 ) Pub Date : 2024-09-19 , DOI: 10.1016/s2213-2600(24)00226-1 Prof Olivier Sitbon PhD, Andris Skride PhD, Jeremy Feldman MD, Sandeep Sahay MD, Oksana A Shlobin MD, Vallerie McLaughlin MD, Hossein-Ardeschir Ghofrani MD, David Langleben MD, Ed Parsley DO, Gwyn D'Souza MD, Tonya Marmon DrPH, Watiri Kamau-Kelley BS, Renee Jones BS, Ravi Grewal MSHS, Steve Wring PhD, Michelle Palacios PhD, Himanshu Naik PhD, Jill Denning MA, Howard M Lazarus MD, Prof Marc Humbert PhD
The role of serotonin in pulmonary arterial hypertension has been extensively studied in recent decades, with preclinical data strongly indicating involvement in disease pathogenesis; however, clinical studies have yielded mixed results.
中文翻译：
rodatristat 乙基治疗肺动脉高压的安全性和有效性 （ELEVATE-2）：一项剂量范围、随机、多中心、2b 期试验
近几十年来，5-羟色胺在肺动脉高压中的作用得到了广泛的研究，临床前数据强烈表明与疾病发病机制有关;然而，临床研究得出的结果喜忧参半。
更新日期：2024-09-19
中文翻译：
rodatristat 乙基治疗肺动脉高压的安全性和有效性 （ELEVATE-2）：一项剂量范围、随机、多中心、2b 期试验
近几十年来，5-羟色胺在肺动脉高压中的作用得到了广泛的研究，临床前数据强烈表明与疾病发病机制有关;然而，临床研究得出的结果喜忧参半。
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