Recently, a new double-layer simulated moving bed (DL-SMB) process concept was introduced to separate continuously ternary or pseudoternary mixtures. The process exploits an operational similarity between SMB chromatography and fractional distillation using a dividing wall. There are well-established concepts for designing classical SMB processes that provide two outlet streams. However, for multicomponent and nonlinear isotherm systems, it is difficult to obtain an explicit solution for the short-cut design of the DL-SMB process. We introduce, in this work, an iterative short-cut design method for competitive Langmuir adsorption isotherms based on the triangle theory. For illustration and validation, three cycloketones (cycloheptanone, cyclohexanone, and cyclopentanone) were considered. Using a C18 column and water/acetonitrile mobile phases, the isotherm parameters and dispersion coefficients were experimentally measured. Applying these parameters, feasible operation conditions were identified by the proposed iterative short-cut design method. Performing numerical simulation using the equilibrium dispersion model, the operation conditions predicted by the proposed short-cut design method were validated successfully.

中文翻译：

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用于连续三元混合物分离的双层模拟移动床色谱的捷径设计：Langmuir 等温线


最近，引入了一种新的双层模拟移动床（DL-SMB）工艺概念来连续分离三元或准三元混合物。该工艺利用了 SMB 色谱法和使用分隔壁的分馏之间的操作相似性。设计提供两个出口流的经典 SMB 流程有完善的概念。然而，对于多组分和非线性等温系统，很难获得DL-SMB过程的快捷设计的显式解。在这项工作中，我们介绍了一种基于三角理论的竞争性朗缪尔吸附等温线的迭代捷径设计方法。为了说明和验证，考虑了三种环酮（环庚酮、环己酮和环戊酮）。使用C18柱和水/乙腈流动相，通过实验测量等温线参数和分散系数。应用这些参数，通过所提出的迭代快捷设计方法确定了可行的操作条件。使用平衡分散模型进行数值模拟，成功验证了所提出的捷径设计方法预测的运行条件。