arising from C. Yang et al. Nature Chemistry https://doi.org/10.1038/s41557-023-01212-2 (2023)

In this work Yang et al.¹ claim that an enantioselective Michael addition reaction with a barrier of 16 kcal mol⁻¹ occurs at the single-molecule level in frozen solvent by measuring fluctuations in current flowing across graphene-based molecular devices. The article, however, contains major scientific errors that undermine their conclusions. We highlight issues with the fabrication of the devices, a lack of characterization, discrepancies between theory and experiment, unreliable inelastic electron tunnelling spectra (IETS) and a perceived misinterpretation of noise as evidence of reaction.

arising from C. Yang et al. Nature Chemistry https://doi.org/10.1038/s41557-023-01212-2 (2023)

在这项工作中，Yang 等人¹ 声称，通过测量流过石墨烯基分子器件的电流波动，在冷冻溶剂中，具有 16 kcal ^mol-1 屏障的对映选择性 Michael 加成反应发生在单分子水平上。然而，这篇文章包含了破坏他们结论的重大科学错误。我们强调了设备制造的问题、缺乏表征、理论与实验之间的差异、不可靠的非弹性电子隧道光谱 （IETS） 以及将噪声误解为反应证据。